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Abstract Cardiovascular diseases are the most common diseases in the world especially the developed countries. Fat was observed to be linked to heart disease, as elevated serum cholesterol, triglycerides and low density lipoprotein cholesterol are associated to heart disease. Heating of oil for long period cause many changes in its chemical structure that leads to the formation of large amount of free radicals. These free radicals can attack the cardiac muscle causing myocardial infraction and also attack the wall of the blood vessels causing atherosclerosis. The present study indicate marked increase in the activity of AST, CK and LDH in both serum and tissues. These increase in serum may result from tissue damage in liver and heart. Also there are increased levels of total lipids and lipid fractions in serum and liver of rats fed deep frying oil that may increase the susceptibility to heart disorders. Most spices are known to be a source of many vitamins. They exhibit a wide range of physiological and pharmacological effects. Among the spices with antioxidant properties, coriander seeds (Coriandrum sativum) contain several types of natural antioxidant. It has hypolipidemic effect. So the addition of coriander seeds to food may decrease the susceptibility of heart diseases. |