الفهرس 
Introduction And Aim Of The WorkOnly 14 pages are availabe for public view
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Abstract
Gastroenteropathy is the most common side effect occuring among patients who use non steroidal anti-inflammatory drugs (NSAIDs). It was mentioned that highly selective cyclooxygenase (COX) inhibitors of NSAIDs lack the propensity to cause gastric ulceration. Therefore, this work was carried out to study the effect of indomethacin (a non selective COX- inhibitor) versus celecoxib (a selective COX-2 inhibitor) on the histological structure of the albino rat stomach and the correlated changes of iNOS in it by using immunohistochemistry. Sixty adult male albino rats were used in this study. They were classified into 5 main groups: group I (control group) that consisted of twelve rats and 4 drug treated groups, groups II,III,IV and V. Each consisted of twelve rats that were further subdivided into two equal subgroups, A (received indomethacin) & B (received celecoxib). Group II A and II B received a single high dose of indomethacin (30 mg/kg, B.W.) for group IIA and celecoxib (100 mg/ Kg, B.W.) for group IIB. Groups IIIA, IVA and VA received 1 mg/kg, B.W. of indomethacin as a single low dose for group IIIA and as a daily dose for groups IVA and VA for 1 week and 2 weeks respectively. Groups IIIB, IVB and VB received 15 mg/kg, B.W. of celecoxib as a single low dose for group IIIB and as a daily dose for groups IVB and VB for 1 week and 2 weeks respectively. Sections from the body and pyloric regions of each stomach were prepared. In control rat, The surface and pit cells as well as the mucous neck cells showed a negative immune reaction. The parietal cells and chief cells showed immune reaction of variable intensity ranging from negative to weak positive reaction. In group IIA, there were mucosal and submucosal vascular congestion, cellular infiltrate mucosal oedema in addition to epithelial mucosal shedding in which there was a strong iNOS immune reaction. In group IIIA, there was limited superficial mucosal lesions. The oxyntic glands showed dilatation of some pit lumen, pyknosis and vacuolation of some parietal and chief cells with moderate to strong iNOS immune reaction. A strong immune reaction was observed in the shedded cells. In groups IVA and VA, there were areas with mucosal shedding and others of regeneration. Marked dilatation of the glandular lumen especially in the glandular base was present in group VA. The dilated areas were lined by flat and cubical cells with moderate immune reaction. On the other hand, celecoxib treated groups revealed less mucosal oedema, less mucosal lesions and less immunoreactivity for iNOS than indomethacin treated groups. But they revealed more mononuclear cellular infiltrate. In conclusion: when NSAID is indicated, it is recommended to use celecoxib instead of indomethacin.