الفهرس 
Introduction
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Abstract
Quinoline, isoquinoline and 4-quinolone derivatives constitute an imiportant class of therapeutically active drugs. Some derivatives act as antimalarials, antiamoebic, anthelmentics, or potent antibacterial agents( 1 l.
Our pharmaceutical analytical study includes two famous anthelmentic drugs which are massively administered; due to their efticacy; these drugs are: oxamniquine and praziquantel, also some 4- quinolone antibacterials which are the drugs of choice due to their effects against many pathogenic microorganisms. The structure ofthe studied compounds and their uses are illustrated in (Table I).
It is the (1,2,3,4 tetra hydro-2-[isopropylamino ethyl] 7-nitro-6- quinoline methanol)( 2) , this derivative has been shown to possess higher schistosomicidal activity than that of its parent methyl compound, 2-N isopropyl amino methyl-6- methyl 7-nitro 1,2,3,4 tetra hydroquinoline,
which is metabolized to oxamniquine(3). It has been reported that, the drug inhibits DNA, RNA and protein synthesis in schistosomes. The oral bioavailability of oxamniquine is good and effective plasma level is achieved in 1 to 1.5 hours. The drug is effective in all stages of infection and in patients with hepatosplenic involvement.
Oxamniquine is readily absorbed following oral ingestion, and a peak concentration in plasma occurs within about 3 hours. The presence of food significantly delays absorption and limits plasma concentration during the first several hours after administration. Excretion is the major route of elimination in man. Only a small portion of the drug is excreted