الفهرس 
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Abstract
The aim of this study is to check for the association of cell proliferation markers including DNA ploidy, apoptosis, p53 and Bcl-2 expression -as determined by flowcytometry- with diagnosis and prognosis of brain tumours in 90 cases that were candidates for surgery.
Malignant tumors showed significant increased levels of mutant p53 expression, S phase of both diploid and aneuoploid cells than benign ones (P<0.05). Significant increased expression of mutant p53 was also observed among recurrent cases (p<0.05) than cases that become free of symptoms. Thus cellular markers can help in prediction of prognosis with potential impact on management plans.
And To check for the association of polymorphisms of cytokine genes with brain tumours in Egyptian cases.
This work has included 45 cases affected by brain tumors. Their median age was 45 years and their sex included 20 males and 25 females. They were taken from the cases presenting to the Neurosurgery Department of Mansoura University Hospital, Egypt. Cases genotypes were compared to 98 healthy unrelated controls from the same locality. Cytokine gene polymorphisms have a certain pattern among brain tumour cases and can be considered a genetic marker of potential value in counseling and management