الفهرس | Only 14 pages are availabe for public view |
Abstract H. pylori organisms are microaerophilic, nonsporulating, gram negative curved rods, with a spiral periodicity in fresh cultures and spherical (coccoid) forms present in older cultures. Growth is best on chocolate or blood agar plates after incubation for 2 to 5 days and present in the stomach. H.pylori infection is associated with increased incidence of gastits, peptic ulcer disease and gastic cancer. There is also an association between H. pylori infection and several extragastrodueodenal pathologies as well as micronutient deficiencies. Detection of H. pylori DNA in materials obtained non-invasively (e.g: non gastric fluids such as saliva and stool) is of great value because this would not only allow for diagnosis but also for genotyping, susceptibility testing, detection of virulence markers and also provide an easier approach to investigate routes of transmission Doxycycline-based therapy proved to be a highly effective third-line ‘rescue’ therapy, achieving 91% eradication rate in patients harbouring metronidazole and clarithromycin resistant H. pylori strains Olive oil, garlic, green tea, lactobacilli and vitamin C are known by their anti- H.pylori activity and can be used as an alternative therapy either alone or combined with other medications . Genetic engineering has been used for developing H. pylori vaccines. Using lactose as an adjuvant may improve the immune effect. |