الفهرس | Only 14 pages are availabe for public view |
Abstract Nutrition, metabolism, inflammation and immunity are strictly related.The intention to regulate the metabolism and some biological system functions by using specific nutrients with pharmacological effects is efined ‘‘pharmaconutrition’’. This is the use of specific artificial nutrients with biologic properties to modulate, Improve or control physiologic or physiopathologic processes. The interaction between nutrition and immune function plays a key-role in the development of many critical diseases and offers preventative and therapeutic opportunities to control the incidence or severity of those diseases. The potential to modulate the immune system by specific nutrient interventions is now becoming a reality. The administration of pharmaconutrients should be dissociated from the provision of parenteral or enteral nutrition so that their full dose can be delivered, either parenterally or enterally, and their therapeutic effects evaluated appropriately. The most important substances involved in this aspect of artificial nutrition in recent years are glutamine, arginine, ω-3 fatty acids and nucleotides. Nutrigenomics, the success of the Human Genome Project and the powerful tools of molecular biology have ushered in a new era of medicine and nutrition. Nutrigenomics refers to the prospective analysis of difference among nutrients with regard to the regulation of gene expression. |