الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Hypercholesterolemia and diabetes mellitus represent the major public health disease affecting different body organs. Eighty fertile male and virgin female rats were used for experimentation. Females were mated in a special cage (1male/3 females) during overnight and gestation was determined in the next morning by the presence of sperm in a native vaginal smear. The pregnant rats were arranged into three groups; control, experimental diabetic and Experimental hypercholesterolemia. Each of the experimental groups was sacrificed at 7, 13, 15, 17 & 19 days prenatal and embryos were separated. The resorption sites were determined. Diabetic and hypercholesterolemic mothers exhibited significant increase of serum cholesterol level, LDL and creatine phosphokinase activity. Highest incidence was detected in hypercholesterolemic mother.increasing the incidence of aborted mothers being highly susceptible in experimental diseased groups. Incidence of abortion was marked increase in experimental hypercholesterolemia < experimental diabetes. Examining of the gross morphology of those of experimentally groups revealed the presence of different criteria of congenital abnormalities. Fetuses maternally subjected to either experimental diabetes and or hypercholesterolemia showed a marked retardation of ossification centers in axial and appendicular regions. Massive degeneration of the endothelial cells were detected in blood vessels of hind limb,liver and heart. retarded development of cartilage cells in different parts of the tibia. massive damage and necrotic disintegration of may hepatocytes. The cardiac muscle possessed apparent appoptic cell death and infiltrated by dense fat lipid deposits causing obliteration of fibers arrangement.The rate of diffusion and density of hepatocyte alkaline phosphatase isoenzyme activities and LDHase of tibia & cardiomyocyte of 13, 15, 17 & 19 days old embryo of either diabetic or hypercholesterolemic mothers were altered. DNA fragmentation with highest incidence in those of diabetic mothers. increase of tail length and DNA concentrations in cardiomyocytes of developing embryos. The skeletal elements of tibia of fetuses of both diabetic and hypercholesterolemic mothers exhibited numerical increase of apoptic cell death.