الفهرس | Only 14 pages are availabe for public view |
Abstract Chronic renal failure (CRF) is a major cause of morbidity and mortality among population. Cardiovascular disease is the main cause of morbidity and mortality in chronic renal patients. Cardiovascular disease in these population can not be fully explained by high prevalence of traditional risk factors, however non traditional risk factors (inflammation and oxidative stress) can contribute to the accelerated development and progression of cardiovascular disease. Chronic microinflammation is a common feature of chronic renal patients. Inflammation progresses as pre-ESRD worsens, also the inflammatozy process is probably augmented by components of renal replacement therapy. Inflammation is marked by elevated levels of CRP. Elevated• levels of CRP are paralleled and caused by enhanced production of proinflammatory cytokines, mainly JL-6. On the other hand, the synthesis of negative acute-phase protein such as albumin is reduced. Previous studies found that both elevation of CRP and diminished serum albumin are associated with increased mortality. This study aims to investigate the value of IL-6 and CRP, as markers of chronic inflammation, in CRF and hence their importance in predictive future IHD as mentioned by previous studies. This study was carried out on 50 subjects. These subjects were classified into 3 groups. Group A included 10 healthy subjects as a control group. Group B included 20 patients with chronic renal failure under conservative treatment (pre-dialysis group). Group C included 20 patients with chronic renal failure under dialysis treatment (haemodialysis group). |