الفهرس | Only 14 pages are availabe for public view |
Abstract Glycoside synthesis as a very common reaction in nature providing a great variety of oligosaccharides and glycoconjugates as glycolipids, glycoproteins and glycopeptides. As recognized only recently, the structural diversity of the oligosaccharide portion, which is inherent in the variability in the glycoside and specificity. For this fact, the field of the synthetic carbohydrate chemistry grow up exponentially in the last twenty years in order to synthesize oligosaccharides for specific purposes which include their use in antibody production, screening of antibodies, lectin and selection specificity, interaction studies with virus1,2 and bacterial receptors3-5, substrates for glycosidases6,7 and glycosyltransferases8 and probes in molecular recognition studies including conformational analysis. To date, it is the challenge for the synthetic chemist to built up glycosidiclinkages with high region- and stereocontrol similar to the naturally occurring ones. Two different approaches are generally used for the O-glycoside bond formation: - Enzymatic O-glycoside bond formation - Chemical O-glycoside bond formation |