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Abstract Iron is the mast abundant element in the earth’s crust. Its Hility, importance and essential ity in different aspects of lire are so great hat it has been high-light,~ned in the Holy Quaran as ”We sent aforetime our Messengers with clear signs and sent down with them The Book and The Balance (of right and wrong) that men may stand forth in justice and we sent down IRON in which is great might as well as many benefits for mankind (Holy QuorLIn, Sorat (57), verse (25). Iron deficiency anemia is the most common form of anemia world wide. Helicobacter pylori is one of the most common human bacterial infection in the world as it infects about one half of the world’s population. H. pylori infection is common in Egypt and acquisition of infection occurs early in life at a very young age. It is linked with adverse spectrum of gastrointestinal clinical disorders as pep!ic ulcer and cancer as the main reservoir is the human stomach. Many reports sho\\ also that this organism causes a variety of extraintestinal manifestations in children including unexplained iron deficiency anemia in absence of gastro intesti na I bleeding. The present study wa, carried out in Banha University Hospital _ Pediatric Department and Clinical Pathology Department to study the prevalence of H. pylori IgG in iron defrciency cases. For this purpose 79 children with mean age 45.3 ± 23.8 months, diagnosed as having iron deliciency anemia, were enrolled in this study t<;Jgemer with 20 healthy children, matched for age and sex, as control group. Our 79 cases (group I) were subdivided into group 11, anemic H. pylori -ve, and group III, anemic H. pylori +ve, while the control group was IV. It is clear from this study that all the different anemic groups showed sig.lli Iicantly lower Hb level than their controls. In anemic H. pylori +ve, Hb level was significantly lower than that 111 anemic H. pylori -\ e cases. All the studied groups showed statistically signiticant lower serum iron levels than health v controls. But both H. ~ . pylori +n: and H. p> lori -ve patients did not show statistically signiticant difference in serum iron levels. Serum ferritin level was statistically signiticantly hig.her in healthy controls than serum ferritin of the other three groups. Serum levels in H. pylori +ve patients were significantly lower compared to H. pylori -ve cases. Total iron binding capacity was signiticantly lower in control group than the other three studied groups. It does not shov, an> signilicant difference between H. pylori -t-ve and H. pylori -\C cases. H. pylori serum IGg was signiticantly higher in patients compared to health) control g.roup. Anemic H. pylori +ve showed statistically significant difference than anemic H. pylori -ve cases. No significant difference between conllo!s and anemic H. pylori -ve cases. The IgG positive cases represent 54.43% of the whole anemic patients and only 10’% or the controls. ’The IgG % cases were highly statistically significant than in control group. So, in conclusion and for recommendation, patients with iron deficiency anemia who are not responding to iron therapy and without any apparent cause for their iron deficiency anemia should be investigated for the presence of H. pylori. Cases who are proved to be anagement. |