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Abstract This study was conducted on 50 male subjects, divided into five groups: oGroup I: Included 10 well-cross-matched healthy volunteers. oGroup II: Included 10 patients with diabetes mellitus. They were normotensive, non-obese, non-smokers. oGroup III: Included 10 patients with hypertension. They were non-diabetic, non-obese, and non-smokers. oGroup IV: Included 10 heavy smoker persons. They were non-obese, non-diabetic, and normotensive. oGroup V: Included 10 obese persons. They were normoten-sive, non smokers, non-diabetic. Every case was subjected to the following investigations: - Plasma fibrinogen level - FDPs level - Plasminogen level - Thrombin time - Partial thromboplastin time Page 133 Summary & Conclusion The following had been reported in this work: o Thrombin time in all groups is less than in control group with statistically significant difference, (Table 6). o Partial thromboplastin time decreased in all groups than in control group with statistically significant difference, (Table 7). o Fibrinogen in all groups is higher than in control with statis-tically highly significant difference, (Table 8). o Plasminogen in all groups is lower than in control group with statistically significant difference, (Table 9). o Fibrin degradation products within normal in all groups (Table 10). o Insignificant correlation between different haemostatic parameters and level of blood sugar in diabetic patients, (Table 11). o Insignificant correlation between different haemostatic parameters and degree of blood pressure in hypertensive patients, (Table 12). o Insignificant correlation between haemostatic parameters and body mass index in obese individuals, (Table 13). Page 134 Summary & Conclusion So, it can be concluded that the hypercoagulability state ob-served in the patients under study, as marked by low thrombin time, partial thromboplastin time, plasminogen and high level of fibrinogen, predisposes them to thrombotic occlusion. In the present work, no significant correlation was found between the dif-ferent haemostatic parameters and the following: Blood sugar in diabetic patients, body mass index in obese individuals, and degree of hypertension in hypertensive patients. So, it can be concluded that, it is the disease itself and not its severity which predispose the patient to hypercoagulability state. |