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العنوان
Plasma fibrinogen, fibrin degradation products and plasminogen levels in patients at risk of development of ischaemic heart disease /
المؤلف
Hany, Amany Mohammed Ismail.
هيئة الاعداد
باحث / أمانى محمد اسماعيل هانى
مشرف / محمد على الهندى
مشرف / مها صلاح الدين يوسف
مشرف / محمد شوقى السيد
الموضوع
Clinical pathology. Coronary heart disease.
تاريخ النشر
1992.
عدد الصفحات
175 p. ;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض الدم
تاريخ الإجازة
1/1/1992
مكان الإجازة
جامعة بنها - كلية طب بشري - الباثولوجى الاكلينكى
الفهرس
Only 14 pages are availabe for public view

from 194

from 194

Abstract

This study was conducted on 50 male subjects, divided into five groups:
oGroup I: Included 10 well-cross-matched healthy volunteers.
oGroup II: Included 10 patients with diabetes mellitus. They were normotensive, non-obese, non-smokers.
oGroup III: Included 10 patients with hypertension. They were non-diabetic, non-obese, and non-smokers.
oGroup IV: Included 10 heavy smoker persons. They were non-obese, non-diabetic, and normotensive.
oGroup V: Included 10 obese persons. They were normoten-sive, non smokers, non-diabetic. Every case was subjected to the following investigations: - Plasma fibrinogen level
- FDPs level
- Plasminogen level
- Thrombin time
- Partial thromboplastin time
Page 133
Summary & Conclusion
The following had been reported in this work:
o Thrombin time in all groups is less than in control group with statistically significant difference, (Table 6).
o Partial thromboplastin time decreased in all groups than in
control group with statistically significant difference, (Table 7).
o Fibrinogen in all groups is higher than in control with statis-tically highly significant difference, (Table 8).
o Plasminogen in all groups is lower than in control group with statistically significant difference, (Table 9).
o Fibrin degradation products within normal in all groups (Table 10).
o Insignificant correlation between different haemostatic
parameters and level of blood sugar in diabetic patients, (Table 11).
o Insignificant correlation between different haemostatic
parameters and degree of blood pressure in hypertensive patients, (Table 12).
o Insignificant correlation between haemostatic parameters and body mass index in obese individuals, (Table 13).
Page 134
Summary & Conclusion
So, it can be concluded that the hypercoagulability state ob-served in the patients under study, as marked by low thrombin time, partial thromboplastin time, plasminogen and high level of
fibrinogen, predisposes them to thrombotic occlusion. In the
present work, no significant correlation was found between the dif-ferent haemostatic parameters and the following: Blood sugar in diabetic patients, body mass index in obese individuals, and degree of hypertension in hypertensive patients. So, it can be concluded that, it is the disease itself and not its severity which predispose the patient to hypercoagulability state.