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Abstract
This study was undertaken to detect early subclinical renal dysfunction by detecting micro albuminuria, and to screen haematological changes occuring in such patients without clinical renal dysfunction, and to correlate this changes to the disease activity.
Forty RA patients (35 females and 5 males) diagnosed according to ACR criteria (1987), were included in the present study, and control group of 20 subjects (18 females and 2 males) matched for sex and age.
All selected patients and controls were subjected to full history, clinical examination, laboratory investigations including, complete urine analysis, serum urea, serum creatinine, fasting and past prandial blood sugar, Latex, ESR, C reactive protein, complete blood picture, serum iron, total iron binding capacity, and micro albuminuria measured by the immunochemical semiquantitative method ”Micral test strips”.
Our results showed micro albuminuria to be a sensitive detector of subclinical renal dysfunction, which was found to be present in 35% of RA patients. Micro albuminuria was found also to be correlated with disease activity, especially the higher grades.
We found also micro albuminuria to correlate with extra-articular manifestations of RA, and disease duration. On the other hand, we found no statistical correlation.