الفهرس | Only 14 pages are availabe for public view |
Abstract Psoriasis vulgaris is a skin disease characterized by hyperproliferation of epidermal keratinocytes, capillary elongation, accompanied by inflammatory cell infiltrate. Keratinocytes hyperproliferation could be explained by dysregulation of growth factors controlling epidermal proliferation and by altered metabolism of their receptors in affected skin. Transforming growth factor beta 1 regulates the proliferation and differentiation of cells, wound healing, and angiogenesis. It is a potent inhibitor of cells as it arrests the cell cycle in the G1 to S phases. It shows a multitude of effects on cellular differentiation and growth. |