Sayed elshayeb

اختيار الموقع	تسجيل دخول

Study of the risk factors for hepatocellular carcinoma: effect of their synergism /
Ibrahim Baghdady - جامعة المنوفية - كلية الطب
Nabil EI-Kaffrawy - جامعة المنوفية - كلية الطب
Ehab Abd EI-Atti - جامعة المنوفية - كلية الطب
Sayed elshayeb - جامعة المنوفية - كلية الطب
Nasser Abd EI-Bary - جامعة المنوفية - كلية الطب
Mohamed Fathi Saber - جامعة المنوفية - كلية الطب

الكلمات الدالة Risk factors associated with HCC are well documented, but the synergism between these
risk factors are not well examined. The aim of this study was to detect the effect of synergism of two or more risk
factors on the development of HCC. Patients & methods: This is a retrospective study of the risk factors of HCC in
300 patients with HCC and 50 patients with chronic liver diseases without HCC as controls. All patients were
interviewed about smoking, drinking and family history of HCC. They underwent laboratory investigations
(HCVAb, HBsAg, Alpha-fetoprotein and HCV PCR), abdominal ultrasonography and Triphasic CT. Results:
Prevalence rate of DM and smoking was significantly higher in HCC cases (59.3% and 69% respectively) than
controls (38% and 50% respectively)(P=0.005 and 0.006 respectively). The prevalence of HBsAg and HCVAb was
significantly higher in HCC cases (18% and 70% respectively) than controls (4% and 40% respectively)( P =0.02
and 0.0001 respectively). On multivariate analysis, the risk of HCC development in smokers with HBV or HCV was
4.90 and 8.47 respectively (OR) (P =0.0001). It was higher than in non-smokers with HBV or HCV (OR=2.48 and
4.44 respectively)( P =0.037 and 0.0001 respectively) and in smokers without HBV or HCV (OR=2.56 and 2.77
respectively) (P =0.01). The risk of HCC development in HBV or HCV positive patients with DM was 3.98 and
9.19 respectively (OR) (P =0.001 and 0.0001 respectively). It was higher than for HBV or HCV positive patients
without DM (OR=2.80 and 4.65 respectively)( P =0.031 and 0.0001 respectively) and that for HBV or HCV
negative patients with DM (OR=2.56 and 2.23 respectively)( P =0.011and 0.0001 respectively).Conclusion, HCV
and HBV infections, diabetes and smoking are the main determinants of HCC development in Egypt. There is a
synergistic effect of many risk factors. An active surveillance and secondary prevention programs for patients with
chronic hepatitis are the most important steps to reduce the risk of HCC.
الصفحات 211-217 p.
تم النشر في : Journal of American Science
تم النشر بتاريخ : 01/09/2011
الملحقات : 1 - Copy.docx

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